![]() Metalloproteinases (MMPs) are a family of endopeptidases participating in the degradation of extra cellular matrix and basement membrane barriers.5 6 7 Some members of the MMPs family have been shown to promote tumor growth, angiogenesis, invasion and metastasis in cancer patients.8 9 10 Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and others essential extra cellular matrix component̀s, being involved in the tumor cell invasion and metastasis.11 12 The mortality rate due to the disease presents an upward curve,1 contributing to make breast cancer a major public health problem and an important cause of mortality in adults.2 In 2018, 59,700 new cases were estimated in Brazil, representing an incidence rate of more than 56 cases per 100,000 women.1 Approximately 10 to 15% of breast cancer patients have a previous family history of the disease however, only 5% can be explained by mutation of genes such as BRCA1 and BRCA2.3 Regarding family risk for the development of the disease, it is necessary to consider the influence of environmental factors and genetic variations that may alter the predisposition to the risk of breast cancer.4 We did not observe a relationship between MMP-9-1562 C/T polymorphism (rs 3918242) and the occurrence of breast cancer.īreast cancer is the most common type of cancer in the female population when disregarding cases of non-melanoma skin cancer. ![]() We also found no association with more advanced disease, the presence of hormone receptors, human epidermal growth factor receptor 2 (HER2) overexpression, or rate of tumor cell proliferation. The DNA was extracted from plasma samples, and the gene was amplified by polymerase chain reaction (PCR) the presence of the polymorphism was determined using restriction enzymes.Īfter adjusting for confounding variables, we found that the polymorphism was not associated with the occurrence of breast cancer (odds ratio = 1.159, 95% confidence interval : 0.6625-1.997, p = 0.5964). In this case-control study, the frequency of the MMP-9-1562 C/T polymorphism (rs 3918242) was determined in 148 women with breast cancer and 245 women without the disease. Our objective was to evaluate the relationship between the MMP-9-1562 C/T polymorphism (rs 3918242) and the risk of developing breast cancer. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix components, being involved in the tumor cell invasion and metastasis. Rogério Tadeu Felizi, Melissa Gonzalez Veiga, Ivo Carelli, Ricardo Peres do Souto, César Eduardo Fernandes, Emerson Oliveira Abstract ObjectiveĮpidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. ![]() ![]() Revista Brasileira de Ginecologia e Obstetrícia Revista Brasileira de Ginecologia e Obstetrícia Associação entre o polimorfismo do gene metalopeptidase de matriz 9 e o risco de câncer de mamaĭOI: 10.1055/s-0038-1673366 - volume 40 - Outubro 2018 ![]()
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